Caffeine is a great example. Although the CYP1A2 gene is analyzed for caffeine metabolism in all tests, each report focuses on different information and provides different recommendations depending on your client’s goals. The Health and Plant-Based reports focus on risk of heart attack and hypertension based on caffeine consumption and your client’s genotype. The Sport report highlights the effects of caffeine on endurance performance, while still identifying potential risks to heart health. The Fertility report focuses on caffeine’s effects on time to establish pregnancy, as well as pregnancy-associated health conditions such as pre-diabetes and hypertension. Your recommendations would essentially be the same regardless of which report you ordered, but the implications would depend on your client’s interest. So, if you are a ‘slow’ metabolizer of caffeine, you would be advised to limit your caffeine intake to no more than 200 mg/day to reduce your risk of cardiovascular disease (e.g. Health or Plant-Based report) or to optimize your performance (e.g. Sport Report). The exception would be the Fertility report, where the recommendation is to limit your intake to no more than 100 mg/day based on the science linking caffeine to pregnancy outcomes.